ODCs

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1 OMIM reference -
1 associated gene
7 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

4 OMIM references -
4 associated genes
4 signs/symptoms

Foveal hypoplasia - presenile cataract

Microphthalmia - cataract


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	PAX6	(0.82)	VSX2

Citations in the biomedical literature:

Foveal hypoplasia - presenile cataract		Microphthalmia - cataract
	Synonym(s): - O'Donnell-Pappas syndrome		Synonym(s): - Congenital cataract - microphthalmia

	Classification (Orphanet): - Rare eye disease - Rare genetic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease

	Classification (ICD10): - Diseases of the eye and adnexa -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: adulthood Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 1 OMIM reference - No MeSH references		External references: 4 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Foveal hypoplasia - presenile cataract		Microphthalmia - cataract
	Very frequent - Anomalies of eyes and vision - Cataract / lens opacification - Diffuse / generalised skin hyperpigmentation / melanoderma - Nystagmus - Optic nerve anomaly / optic atrophy / anomaly of the papilla Frequent - Strabismus / squint		Frequent - Anophthalmos / anophthalmia / microphthalmos / microphthalmia - Coloboma of iris - Retinoschisis / retinal / chorioretinal coloboma